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US 10,954,502 B2Granted
Thrombin-thrombomodulin fusion proteins as protein C activators
AssigneeSaint Louis University
InventorsSergio Barranco-Medina, Nicola Pozzi, Enrico Di Cera
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Abstract
Compositions and methods for regulating the blood coagulation pathway are disclosed. More particularly, the present disclosure relates to thrombin-thrombomodulin fusion proteins, vectors, host cells and methods for preparing the thrombin-thrombomodulin fusion proteins. The present disclosure further relates to methods for measuring protein C in plasma and kits for measuring protein C in plasma.
Claims4
A recombinant thrombin-thrombomodulin fusion protein comprising:
- a) a thrombin domain, wherein the thrombin domain is selected from the group consisting of a full-length thrombin polypeptide, a preprothrombin polypeptide, a prothrombin polypeptide, a prethrombin 1 polypeptide, a prethrombin 2 polypeptide, a thrombin A chain, a thrombin B chain, and combinations thereof, and wherein the full-length thrombin polypeptide is set forth in SEQ ID NO:3 or SEQ ID NO:5;
- and
- b) a thrombomodulin domain, wherein the thrombomodulin domain is selected from the group consisting of a full-length thrombomodulin protein and a thrombomodulin epidermal growth factor-like domain 456 (TM456), and wherein the thrombomodulin epidermal growth factor-like domain 456 (TM456) is set forth in SEQ ID NO:7 or SEQ ID NO:9.
Dependencies are inferred from the claim text.