Biocompatible nanoparticle and use thereof
AssigneeKyungpook National University Industry-Academic Cooperation Foundation
InventorsJeongsoo Yoo, Woonghee Lee
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Abstract
The present invention relates to a biocompatible nanoparticle and a use thereof and, more specifically, to a biocompatible nanoparticle formed by irradiation an electron beam to an aqueous solution comprising at least one substance selected from the group consisting of a polysaccharide, a derivative thereof and a polyethylene glycol, thereby inducing inter-molecular cross-linking or intra-molecular cross-linking, and to a use of the biocompatible nanoparticle in a drug carrier, a contrast agent, a diagnostic agent or an intestinal adhesion prevention agent or for disease prevention and treatment.
Claims1
A method for preparing biocompatible nanoparticles, the method comprising:
- (a) adding to water, at least one material selected from the group consisting of polysaccharides, and a mixture of a polysaccharide and polyethylene glycol to prepare a 0.1% (w/v) to 15% (w/v) solution;
- and
- (b) irradiating the solution prepared in step (a) with an electron beam at a dose of 5 to 250 kGy to crosslink the material, wherein the biocompatible nanoparticle is formed exclusively by inter-molecular or intra-molecular crosslinking of at least one selected from the group consisting of a polysaccharide, and a mixture of a polysaccharide and polyethylene glycol,
- wherein the method excludes the use of a crosslinking agent, a curing agent, an inorganic material, and an organic solvent,
- wherein the polysaccharide is at least one selected from the group consisting of mannan, α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, fructo-oligosaccharides, isomalto-oligosaccharides, inulin, glycogen, amylose, carboxymethyl dextran, beta-glucan, fucoidan, and chondroitin,
- wherein a size of the nanoparticle is in a range of 1 to 700 nm.
Dependencies are inferred from the claim text.