Synthesis of haloindenes
AssigneeThe Florida International University Board of Trustees
InventorsStanislaw F. Wnuk, Md Abu Hasan Howlader
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Abstract
The subject invention provides an expedited synthesis of 5, 6, and 7-iodoindenes from the corresponding aminoindan-1-ones in more than 70% yield, employing readily available precursors and reagents. A three-step sequence involves diazotization-iodination of aminoindan-1-one followed by reduction and dehydration. The method has a general character and can be extended for the preparation of various 4-, 5-, 6- or 7-haloindenes using different halogen sources for diazotization-halogenation reaction.
Claims16
A method for synthesizing a haloindene comprising:
- mixing a nitrite compound and one or more halogen sources with aminoindan-1-one to produce haloindanone;
- adding a reducing agent to said haloindanone to produce haloindanol;
- and
- adding an acid to said haloindanol.
A method for synthesizing an iodoindene comprising:
- mixing a nitrite compound and one or more iodine sources with aminoindan-1-one to produce iodoindanone;
- adding a reducing agent to said iodoindanone to produce iodoindanol;
- and
- adding an acid to said iodoindanol.
A composition comprising 4-iodoindene or 7-iodoindene in solid or powder form or in a solvent, carrier, vehicle and/or excipient.
Dependencies are inferred from the claim text.