Imaging agents and methods of use
AssigneeThe Board of Regents of the University of Oklahoma
InventorsVibhudutta Awasthi, Hailey Houson, Gregory Nkepang
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Abstract
An imaging agent and a method of its use for imaging a necrosis in a tissue of a subject. The imaging method may be positron emission tomography (PET). In at least one embodiment the imaging agent comprises 2-deoxy-2-[18F]fluoroglucaric acid (18F-FGA), or a pharmaceutically-acceptable salt thereof. The imaging agent may be disposed in a pharmaceutically-acceptable excipient, carrier, diluent, or vehicle. The imaging agent may be contained within a kit. The disclosure includes in at least one embodiment a method of preparing a radiopharmaceutical such as 18F-FGA for use in imaging.
Claims8
A process for preparing a radiopharmaceutical composition, comprising:
- combining a quantity of 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) with an oxidizing agent, a reaction accelerator, and an alkaline buffering agent to form a first mixture;
- adding a reaction initiator to the first mixture to form a reaction mixture;
- and
- incubating the reaction mixture, wherein substantially all of the 18F-FDG is converted into 2-deoxy-2-[18F]fluoroglucaric acid (18F-FGA) in less than about 10 minutes after adding the reaction initiator, and wherein the conversion of 18F-FDG into 18F-FGA occurs without monitoring and adjusting the pH of the reaction mixture, thereby preparing the radiopharmaceutical composition and, after conversion of the 18F-FDG into 18F-FGA, adding an acid to the reaction mixture to change the pH of the reaction mixture to a pH in a range of about 6.5 to about 7.5.
Dependencies are inferred from the claim text.