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US 10,953,098 B2Granted
Chemical structures for localized delivery of therapeutic agents
AssigneesThe Regents of the University of California, Alchemical Research Holdings, LLC
InventorsJose Manuel Mejia Oneto, Ziyad F. Al-Rashid
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Abstract
The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.
Claims12
A composition comprising:
- a solid implantable biocompatible support comprising a hydrogel, polymer, sugar based biomaterial, protein or poly(amino-acid), each of which is modified;
- and
- at least one binding agent covalently linked to the solid implantable biocompatible support via a linker, wherein the at least one binding agent is one of a pair of binding agents capable of a bioorthogonal reaction in vivo, wherein the bioorthogonal reaction is a reaction between a trans-cyclooctene and a tetrazine.
A composition comprising:
- a solid implantable biocompatible support comprising hyaluronic acid or alginate, each of which is modified;
- and
- at least one binding agent covalently linked to the solid implantable biocompatible support via a linker, wherein the at least one binding agent is one of a pair of binding agents capable of a bioorthogonal reaction in vivo, wherein the bioorthogonal reaction is a reaction between an azide and alkyne.
Dependencies are inferred from the claim text.