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US 10,953,089 B1Granted
Coronavirus vaccine formulations
AssigneeNovavax, Inc.
InventorsGale Smith, Michael J. Massare, Jing-Hui Tian
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Abstract
Disclosed herein are coronavirus Spike (S) proteins and nanoparticles comprising the same, which are suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.
Claims20
An immunogenic composition comprising:
- (i) a nanoparticle comprising a coronavirus S (CoV S) glycoprotein having the amino acid sequence of SEQ ID NO:
- 87, and a non-ionic detergent core;
- (ii) a pharmaceutically acceptable buffer, and
- (iii) a saponin adjuvant.
1 more element
Dependencies are inferred from the claim text.