Agents and compositions for eliciting an immune response
AssigneeCancure Limited
InventorStephen Ralph
Life of this patent
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Abstract
Immune-potentiating compositions include cells exhibiting enhanced antigen-presenting functions. The compositions are generally useful in facilitating the stimulation of host immune cell responses, including selective and targeted immune cell responses, and are particularly useful in the treatment and/or prophylaxis of cancers, tumors and pathogenic infections.
Claims21
A composition comprising a B7 molecule, a 4-1BB agonist and animal cancer or tumor cells, said animal cancer or tumor cells having been contacted with at least one exogenous interferon (IFN) for a time and under conditions sufficient to enhance the antigen presenting function of the cells, wherein
- the B7 molecule is a B7.1 or B7.2 molecule;
- the exogenous IFN is not produced by the animal cancer or tumor cells;
- and
- the animal cancer or tumor cells have been washed to remove the at least one exogenous IFN.
Dependencies are inferred from the claim text.