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US 10,953,023 B1Granted
Phospholipid compounds and formulations
AssigneeApplaud Medical, Inc.
InventorsDaniel J. Laser, Alice Luong, Robert G. Miotke
Life of this patent
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Abstract
The present disclosure provides phospholipid-containing compounds, pharmaceutical compositions and microspheres that exhibit high affinity for mineralized metals. The present disclosure also provides strategies for using said compounds, compositions and microspheres in the treatment of nephrolithiasis or kidney stone disease, and methods of manufacturing and preparing said compounds and compositions.
Claims20
A pharmaceutical composition comprising a compound of Formula Ia
- or a salt, isomer, or salt of an isomer thereof.
A pharmaceutical composition comprising:
- a compound of Formula I
- or a salt, isomer, or salt of an isomer thereof, wherein:
- n is from 10 to 30,
- m is from 1 to 100,
- X is hydrogen, silyl, acyl, aminoacyl, thioacyl, aminocarbonyl, aminoacyl, carbonyloxy, aminothiocarbonyl, aminosulfonyl, amidino, substituted sulfonyl, substituted sulfinyl, carboxy ester, phthalimido, OH, SO3H, or PO3H;
- a compound of Formula II
- or a salt, isomer, or salt of an isomer thereof;
- and
- a compound of Formula III
- or a salt, isomer, or salt of an isomer thereof;
- wherein:
- t is from 10 to 30,
- y is from 1 to 100, and
- z is from 10 to 30;
- and optionally, at least one pharmaceutically acceptable excipient or diluent.
12 more elements
Dependencies are inferred from the claim text.