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US 10,950,424 B2Granted
Method for monitoring the quality of mass spectrometric imaging preparation workflows
OwnerSören-Oliver Deiningerinventor
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Abstract
The invention relates to a method for monitoring a quality of preparation workflows of analytical tissue sections for mass spectrometric imaging using a control sample to be processed and measured alongside the analytical tissue sections on the same sample support and ascertaining if characteristics of the control sample measurement fit into a range of characteristics of separate reference measurements from the same type of control sample.
Claims20
A method for monitoring a quality of sample preparation workflows of an analytical tissue section for mass spectrometric imaging, comprising:
- providing a sample support suitable for mass spectrometric imaging;
- depositing the analytical tissue section and a control sample on the sample support;
- jointly preparing the analytical tissue section and the control sample for analysis under predetermined conditions;
- acquiring mass spectra from the control sample and acquiring spatially resolved mass spectra from the analytical tissue section in a same measurement run;
- subjecting the mass spectra of the control sample to multivariate feature analysis;
- ascertaining if a result of the multivariate feature analysis fits into a range of outcomes established by subjecting a set of reference control mass spectra, which are obtained from control samples of a same type that have been prepared under substantially the same predetermined conditions, to the same multivariate feature analysis;
- and
- tagging a mass spectrometric image produced from the spatially resolved mass spectra of the analytical tissue section with a result of the ascertaining.
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Dependencies are inferred from the claim text.