Systems and methods of treatment using intervention and tasking determination

A system for managing a drug treatment utilizing administration of a drug to a Cushing's syndrome patient, wherein the drug comprises a glucocorticoid receptor antagonist (GRA), the system comprising:

• a database configuration that stores a relationship between differing fields of information stored on multiple differing information systems accessed by the system, the one or more fields of information including any of a patient identifier, patient characteristic, a treatment regimen, drug dose information, drug refill history, symptom reporting, patient or physician communication, or any combination thereof;
• one or more servers on which the relational database resides;
• wherein the system further comprises a processing unit comprising a processor and having instructions recorded on a memory, the processing unit being configured to:
• access and relate any of the one or more fields of information or any combination thereof to a desired result, wherein said desired result comprises proper change in the patients' GRA dose level and one or more of improved patient compliance;
• improved treatment efficacy;
• improved patient outcome;
• improved adherence to a treatment regimen;
• improved adherence to a treatment regimen update;
• and improved adherence to a regimen modification;
• identify patients or their physicians having need for an intervention for achieving a desired result, wherein said identifying need for an intervention comprises identifying, without requiring test results, patients not receiving a proper change in GRA dose, by:
• A) identification by the system of the combination of high starting dose with multiple refills, no scheduled appointments, no upcoming laboratory draws, and patient is elderly;
• or
• B) identification by the system of a low starting dose with multiple refills, and no scheduled appointments;
• wherein said intervention is selected from
• i) increasing said GRA dose when the system identifies that the physician has not increased the patient's dose to a level that will likely generate a therapeutic effect and
• ii) limiting the GRA dosage to avoid unfavorable side effects;
• and
• providing guidance relating to the treatment, or determining whether follow-up blood work was planned;
• and
• task the intervention by outputting an intervention alert or information communication to one or more electronic devices to facilitate the desired result.

A method of managing drug treatment of a Cushing's syndrome patient using an information system having a processor and a relational database, wherein the drug comprises a glucocorticoid receptor antagonist (GRA), the method comprising:

• Accessing, by said processor, a plurality of fields of information relating to said patient or treatment from a plurality of different information systems on which the plurality of fields of information are stored, wherein the plurality of fields of information comprises one or more of a patient identifier, patient characteristic, treatment regimen information, drug dose information, drug refill history, symptom reporting, patient communication, and physician communication, or any combination thereof;
• Relating, by the processor, the fields of information of the plurality using a relational database of the system and identifying patients or their physicians having need for an intervention for achieving a desired result,
• wherein said identifying need for an intervention comprises identifying, without requiring test results, patients not receiving a proper change in GRA dose, by:
• A) identification by the system of the combination of high starting dose with multiple refills, no scheduled appointments, no upcoming laboratory draws, and patient is elderly;
• or
• B) identification by the system of a low starting dose with multiple refills, and no scheduled appointments;
• wherein said desired result comprises proper change in the patient's GRA dose level and one or more of improved patient compliance;
• improved treatment efficacy;
• improved patient outcome;
• improved adherence to a treatment regimen;
• improved adherence to a treatment regimen update;
• and improved adherence to a regimen modification;
• determining, by the processor, a plurality of tasks associated with the intervention with the system
• wherein said intervention is comprises modifying a patient's prescribed GRA dose to provide a modified GRA dose, wherein said modification is selected from
• i) increasing said GRA dose when the system identifies that the physician has not increased the patient's dose to a level that will likely generate a therapeutic effect and
• ii) limiting the GRA dosage to avoid unfavorable side effects;
• and
• providing guidance relating to the treatment or determining whether follow-up blood work was planned;
• and
• tasking, by the processor, the plurality of tasks to multiple different entities by outputting an intervention alert or information communication to said entities according to a particular sequence and/or timing, and
• administering said modified GRA dose to the Cushing's syndrome patient.