Antibodies, compositions, and immunohistochemistry methods for detecting C4.4a
AssigneeVentana Medical Systems, Inc.
InventorsFernando Jose Rebelo do Couto, Zhiming Liao, Yifei Zhu
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Abstract
Antibodies, compositions, systems, and methods for detecting C4.4a, for example immunohistochemistry methods for detecting C4.4a using a C4.4a antibody. The antibody may be obtained by immunizing a host with a C4.4a protein such as a peptide downstream of the signal peptide. The antibodies may be adapted to detect the uPAR-like domain 1 and uPAR-like domain 2. Also featured are methods for diagnosing C4.4a-associated tumors using C4.4a antibodies disclosed herein.
Claims20
A monoclonal C4.4a antibody specific for an epitope within a uPAR-like domain 2 within a human C4.4a protein, said monoclonal C4.4a antibody comprising a heavy chain variable region comprising heavy chain complementarity determining regions H-CDR1, H-CDR2, and H-CDR3, wherein H-CDR1 comprises SEQ ID NO:
- 23, H-CDR2 comprises SEQ ID NO:
- 25, and H-CDR3 comprises SEQ ID NO:
- 27, and further comprising a light chain variable region comprising light chain complementarity determining regions L-CDR1, L-CDR2, and L-CDR3, wherein L-CDR1 comprises SEQ ID NO:
- 31, L-CDR2 comprises SEQ ID NO:
- 33, and L-CDR3 comprises SEQ ID NO:
- 35.
Dependencies are inferred from the claim text.