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US 10,948,437 B2Granted
Method for analysis using X-ray fluorescence
AssigneeIcagen, Inc.
InventorsLori J. Peterson, Camaron A. Mortillaro, Benjamin P. Warner, Nathan H. Zahler, Pratima Bharti, Chang-Tai Hsieh, Emilia A. Solomon
Life of this patent
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Abstract
The present invention is a method to quantify biomarkers. The method uses an X-ray florescence spectrometer to perform an X-ray fluorescence analysis on the sample to obtain spectral features derived from the biomarker; and quantifying the X-ray fluorescence signal of the biomarker.
Claims15
A method for measuring a response to a cancer therapy comprising
- obtaining a sample which has been exposed to a therapy and a sample which has not been exposed to a therapy, the samples each comprising a biomarker comprising one or more chemicals that are related to a cancer, wherein the samples are prepared for X-ray analysis by exposure to a solution;
- using an X-ray fluorescence spectrometer to perform an X-ray fluorescence analysis on the samples to obtain spectral features derived from the biomarker;
- and
- quantifying the X-ray fluorescence signal of the biomarker and comparing the signal of the sample which has been exposed to the therapy and the sample which has not been exposed to the therapy:
- wherein the X-ray fluorescence spectrometer irradiates the sample with polychromatic X-rays.
2 more elements
Dependencies are inferred from the claim text.