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US 10,947,593 B2Granted
Biomarkers for premature birth
AssigneeThe Chinese University of Hong Kong
InventorsStephen Siu-Chung Chim, Chee Yin Cheung, Wan Chee Cheung, Tak Yeung Leung, Wing Shan Lee
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Abstract
The present invention provides a method for determining increased risk of premature birth in a pregnant woman by detecting altered expression level of one or more marker genes in the woman's blood. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for preventing or reducing the likelihood of premature birth.
Claims16
A method for prophylactic treatment of premature birth, comprising the steps of:
- (a) measuring mRNA level of marker gene ATP2B4 in a blood sample taken from a pregnant woman;
- and
- (b) detecting the ATP2B4 mRNA level obtained in step (a) to be higher than a standard control, and determining the woman as having increased risk of premature birth;
- and
- (c) providing prophylactic treatment for premature birth to the woman determined in step (b) as having increased risk of premature birth, wherein the prophylactic treatment comprises administration of an antenatal corticosteroid, a tocolytic drug, or transdermal glyceryl trinitrate.
2 more elements
Dependencies are inferred from the claim text.