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US 10,947,591 B2Granted
Compositions and method for treating complement-associated conditions
AssigneeGenentech, Inc.
InventorsBrian Yaspan, Robert Royal Graham, Amy Dressen, Zhengrong Li, Erich Strauss, Teodorica Bugawan
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Abstract
The invention provides methods and compositions for treating various degenerative diseases (e.g., AMD) with a factor D inhibitor (e.g., anti-factor D antibody or antigen-binding fragment thereof). Also provided are methods of selecting or identifying patients for treatment with a factor D inhibitor. Methods include the use of prognostic and/or predictive biomarkers.
Claims11
A method of treating age-related macular degeneration (AMD) in a patient in need thereof comprising:
- (a) identifying a patient with AMD as more likely to respond to a therapy comprising an anti-factor D antibody, or antigen-binding fragment thereof comprising:
- (i) detecting the presence of at least one AMD-associated polymorphism in a biological sample obtained from the patient, wherein the detecting comprises:
- (1) providing a nucleic acid sample isolated from the biological sample;
- and
- (2) detecting the genotype of the nucleic acid sample for the presence of at least one AMD-associated polymorphism, wherein at least one AMD-associated polymorphism is single nucleotide polymorphism (SNP) rs4698775;
- and
- (ii) identifying the patient as more likely to respond to a therapy comprising anti-factor D antibody, or an antigen-binding fragment thereof, when at least one risk allele is present, wherein at least one risk allele comprises a G at SNP rs4698775;
- and
- (b) treating the identified patient with AMD by administering an effective amount of a therapy comprising an anti-Factor D antibody, or an antigen-binding fragment thereof, to the identified patient.
6 more elements
Dependencies are inferred from the claim text.