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US 10,947,544 B2Granted
Aptamer therapeutics useful in the treatment of complement-related disorders
AssigneeArchemix Corp.
InventorsClaude Benedict, David Epstein, Charles Wilson, Dilara McCauley, Jeffrey Kurz, Markus Kurz, Thomas Greene McCauley, James Rottman
Life of this patent
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Abstract
The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
Claims5
A compound or salt thereof, wherein the compound comprises a polynucleotide of the sequence
- fCmGfCfCGfCmGmGfUfCfUfCmAmGmGfCGfCfUmGmAmGf UfCfUmGmAmGfUfUfUAfCfCfUmGfCmG-3T (SEQ ID NO:4) and 2,3-bis(mPEG-[20 kDa])-propyl-1-carbamoyl;
- wherein fC and fU=2′-fluoro nucleotides, and mG and mA=2′-OMe nucleotides and all other nucleotides are 2′-OH and 3T indicates an inverted deoxy thymidine.
Dependencies are inferred from the claim text.