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US 10,947,537 B2Granted
Method of treating VEGF/VEGFR resistant prostate cancer by combining the therapy with RAC1 inhibitors
AssigneeUniversity of Massachusetts
InventorsHira Lal Goel, Arthur M. Mercurio
Life of this patent
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Abstract
Methods and compositions for treating cancer, e.g., prostate cancer, using a combination of P-Rex1 or Rac1 inhibitors and VEGF/VEGFR-targeted therapy.
Claims8
A method of treating prostate cancer that is resistant to VEGF/VEGFR-targeted therapy in a subject, the method comprising:
- administering to the subject a therapeutically effective amount of a VEGF/VEGFR-targeted therapy;
- and
- administering to the subject a therapeutically effective amount of a Ras-related C3 botulinum toxin substrate 1 (Rac1) inhibitor.
Dependencies are inferred from the claim text.