Protease-resistant systems for polypeptide display and methods of making and using thereof
AssigneeCytomX Therapeutics, Inc.
InventorsSherry Lynn La Porte, Stephen James Moore, James William West
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Abstract
The present invention generally relates to bacterial polypeptide display systems, libraries using these bacterial display systems, and methods of making and using these systems, including methods for improved display of polypeptides on the extracellular surface of bacteria using circularly permuted transmembrane bacterial polypeptides that have been modified to increase resistance to protease degradation and to enhance polypeptide display characteristics.
Claims20
A carrier protein (CP) comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 1, SEQ ID NO:
- 56 and SEQ ID NO:
- 57.
A carrier protein (CP) comprising the amino acid sequence of SEQ ID NO:
- 1.
A carrier protein (CP) comprising the amino acid sequence of SEQ ID NO:
- 56.
A carrier protein (CP) comprising the amino acid sequence of SEQ ID NO:
- 57.
Dependencies are inferred from the claim text.