Bioreactor system and method

A bioreactor system (1;

• 2;
• 3), comprising:
• a disposable bag (44) having an inner space for receiving a biological material and a disposable bag port (200) of predetermined shape for discharging the biological material from the inner space of the disposable bag (44);
• a receiving container (10) for receiving the disposable bag (44), wherein the receiving container comprises:
• a bottom surface (11) configured to support the disposable bag (44) in the receiving container (10), and
• an outlet opening (5) formed in the bottom surface (11) of the receiving container (10), the outlet opening (5) being downwardly tapered relative to Earth's frame of reference;
• and
• a complementary drain port (45) separately and independently of both the disposable bag (44) and the receiving container (10), the complementary drain port (45) having a hollow receptacle (48) mounted around the disposable bag port (200) of the disposable bag (44) and comprising a convex taper that tapers to smaller cross sectional dimensions at positions farther away from the inner space of the disposable bag (44), the convex taper of the complementary drain port being complementary to the downwardly tapered outlet opening (5) of the receiving container.