Functional, segregated, charged telodendrimers and nanocarriers and methods of making and using same
AssigneeThe Research Foundation for The State University of New York
InventorsJuntao Luo, Xu Wang, Changying Shi
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Abstract
Provided are multiply functional charged telodendrimers. The telodendrimers can be used for protein encapsulation and delivery. The charged telodendrimers may have one or more crosslinking groups (e.g., boronic acid/catechol reversible crosslinking groups). The telodendrimers can aggregate to form nanoparticles. Cargo such as combinations of proteins and other materials may be sequestered in the core of the nanoparticles via non-covalent or covalent interactions with the telodendrimers. Such nanoparticles may be used in protein delivery applications.
Claims14
A compound having the following structure:
- wherein
- PEG is optionally present and is a polyethylene glycol moiety, wherein PEG has a molecular weight of 44 Da to 100 kDa;
- X is a branched monomer unit;
- each L1 is independently optional and is a linker group;
- each L2 is independently optional and is a linker group;
- D is a dendritic polymer-having one or more branched monomer units (X);
- R2 is an end group and is independently at each occurrence in the compound selected from the group consisting of positively charged groups, negatively charged groups, hydrophilic groups, and hydrophobic groups, wherein for every group of two R2 groups on the same branched monomer unit, one R2 group of the group the two R2 groups has a positively charged group or negatively charged group and the other R2 group is uncharged;
- subscript n is an integer from 1 to 32;
- and
- subscript m is an integer from 0 to 32, wherein the positively charged group, when present, is chosen from moieties or derivatives or analogs of arginine, guanidine, amidine, secondary amine, tertiary amine, quaternary amine, or tetrazole, and wherein the compound is a telodendrimer.
A compound comprising the following structure:
- PEG5k(ArgArg-L-R)4, wherein R is
A compound having the following structure:
- wherein
- PEG is present and is a polyethylene glycol moiety, wherein PEG has a molecular weight of 44 Da to 100 kDa;
- X is a branched monomer unit;
- each L1 is independently optional and is a linker group;
- each L2 is independently optional and is a linker group;
- D is a dendritic polymer-having one or more branched monomer units (X);
- R2 is an end group and is independently at each occurrence in the compound selected from the group consisting of positively charged groups, negatively charged groups, hydrophilic groups, and hydrophobic groups, wherein for every group of two R2 groups on the same branched monomer unit, one R2 group of the group the two R2 groups has a positively charged group or negatively charged group and the other R2 group is uncharged;
- subscript n is an integer from 1 to 32;
- and
- subscript m is an integer from 0 to 32, wherein the positively charged group, when present, is chosen from moieties or derivatives or analogs of arginine, guanidine, amidine, secondary amine, tertiary amine, quaternary amine, or tetrazole.
Dependencies are inferred from the claim text.