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US 10,947,349 B2Granted
Shape-preserving polymeric replication of biological matter
AssigneeNational Technology & Engineering Solutions of Sandia, LLC
InventorBryan James Kaehr
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Abstract
The present invention relates to a method of forming silica nanolayers on or within a biological sample, thereby capturing structural details that are present in the sample. The resultant silica composite or silica replica, in turn, can be employed as a template for a replica having those structural details captured in a polymer. Also provided herein are synthetic constructs including a polymeric replica, which can have any useful feature (e.g., oxygen-binding capacity).
Claims15
A synthetic construct comprising:
- a polymeric replica of a biological sample, wherein the replica comprises a shape-preserved layer comprising a polymeric precursor or a polymer, wherein the polymer or the polymeric precursor comprises a poly(ethylene glycol) group, an amino acid, a glycerol group, and/or a vinyl group, or polyelectrolyte pairs comprising alternating charge within the layer-by-layer assembly;
- an oxygen carrier loaded within the polymeric replica;
- and
- optionally, one or more endogenous or exogenous oxygen-binding molecules loaded within the polymeric replica.
1 more element
A synthetic construct comprising:
- a polymeric replica of a biological sample, wherein the replica consists essentially of a polymeric precursor or a polymer;
- an oxygen carrier loaded within the polymeric replica;
- and
- one or more endogenous or exogenous oxygen-binding molecules loaded within the polymeric replica, wherein at least one of the one or more endogenous or exogenous oxygen-binding molecules comprises hemoglobin, porphyrin, heme protein, hemerythrin, hemocyanin, methemoglobin, or a modified form, a cross-linked form, a polymerized form, a conjugated form, and/or a recombinant form thereof.
1 more element
Dependencies are inferred from the claim text.