Capped cyclodextrin-hydrophobic moiety conjugate, cyclodextrin supramolecular polymer, and cyclodextrin-siRNA complex and method of synthesis thereof

A capped cyclodextrin-hydrophobic moiety conjugate comprising a cyclodextrin moiety and at least one hydrophobic moiety, wherein:

• the cyclodextrin moiety is capped on its primary rim by a cap binding a first carbon atom, previously bearing a hydroxyl group, of a first glucopyranose unit to a second carbon, previously bearing an hydroxyl group, of a second and different glucopyranose unit, said first and second glucopyranose units being preferably separated from each other by at least one, and
• the hydrophobic moiety is bound by a first linker to one of the carbon atoms of the cap, and
• the hydrophobic moiety is selected from the group consisting of an adamantane group, a C2-C13 alkyl group optionally containing at least one heteroatom, a C5-C6 aromatic group optionally containing at least one heteroatom and a C3-C8 non-aromatic cycle optionally containing at least one heteroatom.