Host-guest metal organic framework systems
AssigneeCommonwealth Scientific and Industrial Research Organisation
InventorsKang Liang, Raffaele Ricco, Cara Maxwell Doherty, Paolo Falcaro
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Abstract
A method for producing Metal Organic Framework (MOF) having a framework that encapsulates a bio-molecule, the method comprising combining in a solution the bio-molecule and MOF precursors, wherein the bio-molecule promotes formation of the encapsulating framework. The method stems from a surprising effect that a bio-molecule can promote or trigger the formation of MOF when combined together in a solution with MOF precursors. That is, it has now been found that a bio-molecule can effectively act as a seed around which the framework forms, with the resulting framework encapsulating the bio-molecule.
Claims11
A method for producing Metal Organic Framework (MOF) having a framework that encapsulates a bio-molecule selected from the group consisting of a protein, a peptide, a nucleic acid, an amino acid, and a combination thereof, the bio-molecule having a smallest dimension that is at least 1.5 times larger than the largest cavity diameter (LCD) of any intrinsic cavity of the framework, and the method comprising combining in a particular order the bio-molecule and MOF precursors that comprise an organic ligand and a metal salt under conditions selected to form a framework that encapsulates said bio-molecule, the particular order being:
- (i) combining a solution comprising both the bio-molecule and the organic ligand with a separate solution comprising the metal salt, or
- (ii) combining together at the same time three solutions each separately comprising the metal salt, the organic ligand, and the bio-molecule, respectively,
- wherein the encapsulating framework is formed around said bio-molecule at a solution temperature that is lower than 75° C., such that the bio-molecule sits within the MOF framework as a bioactive, heterogeneous and discontinuous guest phase within a self-defined cavity.
A method of producing crystalline Metal Organic Framework (MOF) having a framework that defines intrinsic cavities and encapsulates a bio-molecule, said method comprising:
- a) combining in a particular order the bio-molecule, and MOF precursors that comprise an organic ligand and a metal salt, the particular order being:
- (i) combining a solution comprising both the bio-molecule and the organic ligand with a separate solution comprising the metal salt, or,
- (ii) combining together at the same time three solutions each separately comprising the metal salt, the organic ligand, and the bio-molecule, respectively, and
- b) forming the encapsulating framework around said bio-molecule at a solution temperature that is lower than 75° C.,
- wherein the bio-molecule (i) promotes formation of the encapsulating framework, (ii) has a smallest dimension that is at least 1.5 times larger than the largest cavity diameter (LCD) of any intrinsic cavity of the framework, and (iii) sits within the MOF framework as a bioactive, heterogeneous and discontinuous guest phase within a self-defined cavity.
A method for producing Metal Organic Framework (MOF) having a framework that encapsulates a bio-molecule, the method comprising combining in a particular order in a solution the bio-molecule and MOF precursors that comprise an organic ligand and a metal salt, the particular order being:
- (i) combining a solution comprising both the bio-molecule and the organic ligand with a separate solution comprising the metal salt, or
- (ii) combining together at the same time three solutions each separately comprising the metal salt, the organic ligand, and the bio-molecule, respectively,
- wherein
- the bio-molecule promotes formation of the encapsulating framework, and
- the bio-molecule has a smallest dimension that is at least 1.5 times larger than the largest cavity diameter (LCD) of any intrinsic cavity of the framework;
- and
- the encapsulating framework is formed around said bio-molecule at a solution temperature that is lower than 75° C., such that the bio-molecule sits within the MOF framework as a bioactive, heterogeneous and discontinuous guest phase within a self-defined cavity.
Dependencies are inferred from the claim text.