Antibody-drug conjugates containing anti-Globo H antibodies and uses thereof

An immunoconjugate that binds specifically to Globo H, comprising an anti-Globo H antibody or an antigen-binding fragment thereof, and a cytotoxic agent or a label, wherein

• the immunoconjugate has the formula:
• Ab−(L−D)m,
• wherein
• the Ab is the anti-GLOBO H antibody, or the antigen-binding fragment,
• L is a linker or a direct bond,
• D is the cytotoxic agent or the label, and
• m is an integer from 1 to 8,
• wherein the antibody comprises heavy chain variable domain having three complementarity determining regions consisting of HCDR1, HCDR2 and HCRD3, and a light chain variable domain having three complementarity determining regions consisting of LCDR1, LCDR2 and LCDR3, wherein the sequence of HCDR1 is GYISSDQILN (SEQ ID NO:1), the sequence of HCDR2 is RIYPVTGVTQYXHKFVG (SEQ ID NO:2), wherein X is any amino acid, the sequence of HCDR3 is GETFDS (SEQ ID NO:
• 3), the sequence of LCDR1 is KSNQNLLX′SGNRRYZLV (SEQ ID NO:4) wherein X′ is F, Y or W and Z is C, G, S or T, the sequence of LCDR2 is WASDRSF (SEQ ID NO:5) and the sequence of LCDR3 is QQHLDIPYT (SEQ ID NO:6).