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US 10,947,312 B2Granted
Human antibodies to GFRα3 and methods of making thereof
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsSusan D. Croll, Lynn Macdonald, Andrew J. Murphy
Life of this patent
Estimating the term…
Abstract
The present invention provides antibodies that bind to human GFRα3 and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human GFRα3. The antibodies of the invention are useful for the treatment of diseases and disorders associated with one or more GFRα3 biological activities, including the treatment of acute or chronic pain conditions, or inflammatory conditions.
Claims24
An isolated nucleic acid molecule comprising:
- (a) a nucleic acid sequence encoding a heavy chain (HC) of an antibody or antigen-binding fragment thereof that specifically binds to human GDNF receptor alpha 3 (GFRα3), the HC comprising a heavy chain variable region (HCVR) having a heavy chain complementarity determining region 1 (HCDR1) comprising the amino acid sequence of SEQ ID NO:
- 148, a heavy chain complementarity determining region 2 (HCDR2) comprising the amino acid sequence of SEQ ID NO:
- 150, and a heavy chain complementarity determining region 3 (HCDR3) comprising the amino acid sequence of SEQ ID NO:
- 152;
- and
- (b) a nucleic acid sequence encoding a light chain (LC) of an antibody or antigen-binding fragment thereof that specifically binds to human GFRα3, the LC comprising a light chain variable region (LCVR) having a light chain complementarity determining region 1 (LCDR1) comprising the amino acid sequence of SEQ ID NO:
- 156, a light chain complementarity determining region 2 (LCDR2) comprising the amino acid sequence of SEQ ID NO:
- 158, and a light chain complementarity determining region 3 (LCDR3) comprising the amino acid sequence of SEQ ID NO:
- 160;
- wherein the HCVR is encoded by a nucleic acid molecule having at least 90% sequence identity to the nucleic acid sequence of SEQ ID NO:
- 145, and the LCVR is encoded by a nucleic acid molecule having at least 90% sequence identity to the nucleic acid sequence of SEQ ID NO:
- 153.
9 more elements
An isolated host cell comprising two isolated nucleic acid molecules:
- (a) an isolated nucleic acid molecule comprising a nucleic acid sequence encoding a heavy chain (HC) of an antibody or antigen-binding fragment thereof that specifically binds to human GFRα3, the HC comprising a heavy chain variable region (HCVR) and having a heavy chain complementarity determining region 1 (HCDR1) comprising the amino acid sequence of SEQ ID NO:
- 148, a heavy chain complementarity determining region 2 (HCDR2) comprising the amino acid sequence of SEQ ID NO:
- 150, and a heavy chain complementarity determining region 3 (HCDR3) comprising the amino acid sequence of SEQ ID NO:
- 152;
- and
- (b) an isolated nucleic acid molecule comprising a nucleic acid sequence encoding a light chain (LC) of an antibody or antigen-binding fragment thereof that specifically binds to human GFRα3, the LC comprising a light chain variable region (LCVR) having a light chain complementarity determining region 1 (LCDR1) comprising the amino acid sequence of SEQ ID NO:
- 156, a light chain complementarity determining region 2 (LCDR2) comprising the amino acid sequence of SEQ ID NO:
- 158, and a light chain complementarity determining region 3 (LCDR3) comprising the amino acid sequence of SEQ ID NO:
- 160;
- wherein the HCVR is encoded by a nucleic acid molecule having at least 90% sequence identity to the nucleic acid sequence of SEQ ID NO:
- 145, and the LCVR is encoded by a nucleic acid molecule having at least 90% sequence identity to the nucleic acid sequence of SEQ ID NO:
- 153.
9 more elements
Dependencies are inferred from the claim text.