VCAM-1 mediated methods and compositions for treating aging-associated impairments
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsAnton Wyss-Coray, Hanadie Yousef
Life of this patent
Estimating the term…
Abstract
Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include reducing cell surface VCAM-1 activity in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
Claims15
A method of treating a disorder or disease in an adult mammal, the method comprising:
- administering a neutralizing vascular cell adhesion molecule 1 (VCAM-1) antibody or binding fragment thereof to an adult mammal who has a disorder or disease selected from the group consisting of:
- Alzheimer's disease, Parkinson's disease, frontotemporal dementia, Huntington's disease, and amyotrophic lateral sclerosis,
- wherein said administering results in treatment of the disorder or disease.
A method of stimulating neurogenesis and/or blocking neurodegeneration in an adult mammal, the method comprising:
- administering a neutralizing vascular cell adhesion molecule 1 (VCAM-1) antibody or binding fragment thereof to an adult mammal who has Parkinson's disease, frontotemporal dementia, Huntington's disease, or amyotrophic lateral sclerosis, and after said administering,
- measuring neurogenesis and/or microglial reactivity in the adult mammal.
A method of treating a disorder or disease in an adult mammal, the method comprising:
- administering a neutralizing vascular cell adhesion molecule 1 (VCAM-1) antibody or binding fragment thereof to an adult mammal who has a disorder or disease selected from the group consisting of:
- Parkinson's disease, frontotemporal dementia, Huntington's disease, and amyotrophic lateral sclerosis,
- wherein said administering results in treatment of the disorder or disease.
Dependencies are inferred from the claim text.