Gremlin-1 antibody
AssigneeUcb Biopharma Srl
InventorsNeesha Dedi, Breda Twomey, Michael John Wright, Gareth Davies, David James McMillan
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Abstract
This invention relates to crystals of the human Gremlin-1 protein, and the human Gremlin-1 protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-1 (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-1 activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-1, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.
Claims12
A monoclonal anti-Gremlin-1 antibody comprising a HCDR1/HCDR2/HCDR3/LCDR1/LCDR2/LCDR3 sequence combination of SEQ ID NOs:
- 4/5/6/7/8/9 or SEQ ID NOs:
- 3/5/6/7/8/9.
Dependencies are inferred from the claim text.