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US 10,947,300 B2Granted
Agents for influenza neutralization
AssigneeMassachusetts Institute of Technology
InventorsS. Raguram, Viswanathan Sasisekharan, Venkataramanan Soundararajan, Ram Sasisekharan, Vidya Subramanian, Kannan Tharakaraman
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Abstract
The present invention provides antibodies (e.g., monoclonal antibodies, human antibodies, humanized antibodies, etc.), which bind to multiple influenza strains. Such antibodies are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of influenza.
Claims18
A method comprising:
- administering to a subject suffering from or susceptible to influenza infection a therapeutically effective amount of a combination therapy, comprising
- an engineered antibody, or antigen-binding fragment thereof, and one or more therapeutic agents, wherein the antibody comprises:
- (a) a heavy chain variable region that shows at least 99% substantial sequence homology with that of heavy chain variable region of SEQ ID NO:
- 1;
- and
- (b) a light chain variable region that shows at least 99% substantial sequence homology to one of SEQ ID NOs:
- 33-43.
4 more elements
A method comprising:
- administering to a subject suffering from or susceptible to influenza infection an antibody, or antigen-binding fragment thereof, and one or more therapeutic agents, wherein:
- the antibody comprises:
- (a) a heavy chain variable region that shows at least 99% substantial sequence homology with that of heavy chain variable region of SEQ ID NO:
- 1;
- and
- (b) a light chain variable region that shows at least 99% substantial sequence homology to one of SEQ ID NOs:
- 33-43.
4 more elements
Dependencies are inferred from the claim text.