Antibody that binds to envelope glycoprotein of severe fever with thrombocytopenia syndrome virus and use for same
AssigneesSeoul National University R&Db Foundation, Institut Pasteur Korea
InventorsJunho Chung, Ki-Hyun Kim, Hyori Kim, Myoung-don Oh, Wan Beom Park, Seungtaek Kim, Jinhee Kim, Ji-Young Min, Meehyun Ko
Life of this patent
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Abstract
The present invention relates to an antibody which specifically binds to the envelope glycoprotein of severe fever with thrombocytopenia syndrome virus (SFTSV), the pathogen of severe fever with thrombocytopenia syndrome (SFTS), and is used in order to effectively detect or diagnosis SFTSV and treat SFTS.
Claims9
An antibody which specifically binds to Gc that is an envelope glycoprotein of severe fever with thrombocytopenia syndrome virus, wherein the antibody comprises:
- a) LCDR1 of SEQ ID No:
- 21, LCDR2 of SEQ ID No:
- 41, LCDR3 of SEQ ID No:
- 61, HCDR1 of SEQ ID No:
- 26, HCDR2 of SEQ ID No:
- 46, and HCDR3 of SEQ ID No:
- 66;
- b) LCDR1 of SEQ ID No:
- 22, LCDR2 of SEQ ID No:
- 42, LCDR3 of SEQ ID No:
- 62, HCDR1 of SEQ ID No:
- 27, HCDR2 of SEQ ID No:
- 47, and HCDR3 of SEQ ID No:
- 67;
- c) LCDR1 of SEQ ID No:
- 23, LCDR2 of SEQ ID No:
- 43, LCDR3 of SEQ ID No:
- 63, HCDR1 of SEQ ID No:
- 28, HCDR2 of SEQ ID No:
- 48, and HCDR3 of SEQ ID No:
- 68;
- d) LCDR1 of SEQ ID No:
- 24, LCDR2 of SEQ ID No:
- 44, LCDR3 of SEQ ID No:
- 64, HCDR1 of SEQ ID No:
- 29, HCDR2 of SEQ ID No:
- 49, and HCDR3 of SEQ ID No:
- 69;
- or
- e) LCDR1 of SEQ ID No:
- 25, LCDR2 of SEQ ID No:
- 45, LCDR3 of SEQ ID No:
- 65, HCDR1 of SEQ ID No:
- 30, HCDR2 of SEQ ID No:
- 50, and HCDR3 of SEQ ID No:
- 70.
An antibody which specifically binds to Gn that is an envelope glycoprotein of severe fever with thrombocytopenia syndrome virus, wherein the antibody comprises
- a) LCDR1 of SEQ ID No:
- 101, LCDR2 of SEQ ID No:
- 121, LCDR3 of SEQ ID No:
- 141, HCDR1 of SEQ ID No:
- 106, HCDR2 of SEQ ID No:
- 126, and HCDR3 of SEQ ID No:
- 146;
- b) LCDR1 of SEQ ID No:
- 102, LCDR2 of SEQ ID No:
- 122, LCDR3 of SEQ ID No:
- 142, HCDR1 of SEQ ID No:
- 107, HCDR2 of SEQ ID No:
- 127, and HCDR3 of SEQ ID No:
- 147;
- c) LCDR1 of SEQ ID No:
- 103, LCDR2 of SEQ ID No:
- 123, LCDR3 of SEQ ID No:
- 143, HCDR1 of SEQ ID No:
- 108, HCDR2 of SEQ ID No:
- 128, and HCDR3 of SEQ ID No:
- 148;
- d) LCDR1 of SEQ ID No:
- 104, LCDR2 of SEQ ID No:
- 124, LCDR3 of SEQ ID No:
- 144, HCDR1 of SEQ ID No:
- 109, HCDR2 of SEQ ID No:
- 129, and HCDR3 of SEQ ID No:
- 149;
- or
- e) LCDR1 of SEQ ID No:
- 105, LCDR2 of SEQ ID No:
- 125, LCDR3 of SEQ ID No:
- 145, HCDR1 of SEQ ID No:
- 110, HCDR2 of SEQ ID No:
- 130, and HCDR3 of SEQ ID No:
- 150.
Dependencies are inferred from the claim text.