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AssigneeSuzhou Thinking Power Biotechnology Co., Ltd.
InventorsHuashun Li, Baoyong Ren, Peng Liu
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The present invention relates to the field of biomedical technology, in particular to a fusion protein Slit2D2(C386S)-HSA and use thereof in the treatment and/or prevention of fibrotic diseases. In the fusion protein, the amino acid residue is mutated on the basis of the Slit2D2 domain, which improves the stability of the fusion protein compared with the native protein. The above fusion protein is obtained by fusing Slit2D2(C386S) with HSA protein, which prolongs the metabolism time of the drug while improving the stability of the drug. The fusion protein provided by the present invention is more effective than the positive control drug in the prevention and treatment of fibrotic diseases, particularly pulmonary fibrosis, and shows good drug-forming properties.
A polypeptide or protein comprising or consisting of a D2 domain of a Slit2 protein, the Slit2 protein is derived from human, wherein the cysteine in the D2 domain of the Slit2 protein, corresponding to the 5th cysteine of the Slit2 protein, is located at position 386 of the Slit2 protein and is mutated to a polar amino acid.
Dependencies are inferred from the claim text.