Method of stabilizing a bioactive peptide against protease hydrolysis
AssigneesThe Trustees of the University of Pennsylvania, President and Fellows of Harvard College
InventorsE. James Petersson, Alan Saghatelian
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Abstract
The invention includes a thioamide-modified peptide, wherein the thioamide modification increases the in vivo half-life of the peptide. The invention further includes methods of treating or preventing a disease or disorder in a subject in need thereof, the method comprising administering to the subject a thioamide-modified peptide of the invention.
Claims3
A method of stabilizing a bioactive peptide against protease hydrolysis, the method comprising replacing the amide bond formed between the first and second amino acid residues from the N-terminus of the bioactive peptide with a thioamide bond, wherein the protease comprises at least one selected from the group consisting of DPP-4 and carboxypeptidase.
Dependencies are inferred from the claim text.