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AssigneesThe Texas A&M University System, William Marsh Rice University
InventorsSarah Bondos, Kayla Bayless, Kathleen Matthews, Jan Patterson, Colette Abbey, David Howell, Hao-Ching Hsiao, Kelly Churion, Shang-Pu Tsai, Sandhya Ramasamy, Dustin Porterpan, Keira Northern
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Embodiments of the invention are directed to Ubx-fusion molecules that maintain their mechanical strength and properties even after being fused with Ubx. Ubx fusions with VEGF and other growth factors, cell signaling proteins, and cell binding proteins can be used to induce angiogenesis. Ubx fibers and mesh, embedded within a tissue engineering scaffold, induce formation of vasculature within the scaffold. The presence of vasculature is necessary to provide oxygen and nutrients to other cells growing within the scaffold.
A composition comprising at least one Ultrabithorax (Ubx) protein coupled with a first biomolecule, wherein the first biomolecule is a multimeric protein and is not Ubx, wherein the Ubx protein contains mutations within tyrosine residues involved in the formation of di-tyrosine bonds wherein the mutations within tyrosine residues influence formation of di-tyrosine bonds, alter the strength of Ubx materials, and/or alter intensity of blue fluorescence.
A composition comprising at least one Ultrabithorax (Ubx) protein coupled with a first biomolecule, wherein the first biomolecule is a multimeric protein and is not Ubx, wherein the Ubx protein is selected from the group consisting of the full length Ubx protein, SEQ ID NO:
A composition comprising at least one full-length ultrabithorx (Ubx) protein with substitutions within tyrosine residues involved in the formation of di-tyrosine bonds coupled with a first multimeric biomolecule which is not Ubx.
Dependencies are inferred from the claim text.