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US 10,947,277 B2Granted
Nucleic acids encoding zika virus-like particles and their use in zika virus vaccines and diagnostic assays
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsGwong-Jen J. Chang, Brent S. Davis
Life of this patent
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Abstract
Transcriptional units encoding Zika virus (ZIKV) premembrane (prM) and envelope (E) proteins, which upon translation form Zika virus-like particles (VLPs), are described. Use of the transcriptional units and VLPs in three different ZIKV vaccine platforms is described. Immunoassay-based detection methods using ZIKV VLPs are described for the diagnosis of ZIKV infection.
Claims19
A virus-like particle (VLP), comprising a Zika virus (ZIKV) premembrane (prM) protein and envelope (E) protein (prME),
- wherein the ZIKV E protein comprises a glycine to lysine substitution at position 106 and a leucine to aspartic acid substitution at position 107, wherein the numbering is based upon the E protein of ZIKV strain MR766.
Dependencies are inferred from the claim text.