Cell penetrating peptides with improved internalization properties
AssigneesSorbonne Universite, Inserm (Institut National De La Sante Et De La Recherche Medicale), Centre National De La Recherche Scientifique, Pep-Therapy
InventorsAngelita Rebollo, Jesus Maria Fominaya Gutierrez, Jeronimo Bravo Sicilia, Sophie Lebel Binay, Leticia Dominguez Berrocal
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Abstract
A method for delivering a cargo molecule into a cell is described that comprises linking a cargo molecule to a cell penetrating peptide. Chimeric constructs comprising cell penetrating moieties are also provided.
Claims15
A chimeric construct comprising a cargo molecule linked to a cell penetrating moiety consisting of SEQ ID NO:
- 7 or SEQ ID NO:
- 9.
A chimeric (poly)peptide comprising a peptide or a protein and a sequence selected from the group consisting of KKKKKWKKWKKK (SEQ ID NO:
- 7);
- KKKKKWKKW (SEQ ID NO:
- 9);
- RKR-KKKKKWKKW-PKKKKLD (SEQ ID NO:
- 27);
- and RKR-KKKKKWKKWKKK-PKKKKLD (SEQ ID NO:
- 28).
Dependencies are inferred from the claim text.