Peptides of use in the preventive and curative treatment of alopecia
AssigneesInstitut European de Biologic Cellulaire, Centre de Recherches Biologiques et d'Experimentations Cutanees, Centre National de la Recherche Scientifique (CNRS)
InventorsMichel Hocquaux, Stéphanie Almeida Épouse Scalvino, Elian Lati, Joanna Bakala
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Abstract
The object of the present invention relates to a novel family of peptide conjugates of formula (I): A-X1-X2-Pro-Ala-X—B (I) wherein: A represents a hydrogen atom, a C6 to C20 acyl group or a cholesterol residue; X1 represents a covalent bond, an alanine or a proline; X2 represents an arginine, a lysine, or an alanine; X represents a lysine, an alanine, or a phenylalanine; and B represents a hydroxyl or an amine; or one of its preferentially pharmaceutically, dermatologically or cosmetically acceptable salts, as well as their synthesis processes and their uses for reducing hair loss and stimulating hair growth.
Claims14
A peptide conjugate of formula Palm-Ala-Ala-Pro-Ala-Lys-NH2 (SEQ ID NO:6) or a dermatologically acceptable salt thereof,
- wherein
- Palm represents a palmitoyl group.
Dependencies are inferred from the claim text.