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US 10,947,257 B2Granted
Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
AssigneeCompass Pathfinder Limited
InventorsDerek John Londesbrough, Christopher Brown, Julian Scott Northen, Gillian Moore, Hemant Kashinath Patil, David E. Nichols
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Abstract
This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
Claims23
An oral dosage form comprising:
- a therapeutically effective amount of crystalline psilocybin in the form Polymorph A characterized by peaks in an XRPD diffractogram at 11.5, 12.0, 14.5, 17.5, and 19.7°2θ±0.1°2θ, wherein the crystalline psilocybin has a chemical purity of greater than 97% by HPLC, and no single impurity of greater than 1%;
- and
- silicified microcrystalline cellulose.
Dependencies are inferred from the claim text.