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US 10,947,253 B2Granted
Fused polycyclic dimers
AssigneeAnkh Life Sciences Limited
InventorsBrian Scott Johnathan Blagg, Vishal Chandrakumar Birar, Gene H. Zaid
Life of this patent
Estimating the term…
Abstract
Novel fused tricyclic or bicyclic dimers, such as β-carboline and quinoline moieties with a central linker, exhibit anti-cancer activities against a variety of human cancer cell lines. The dimer compounds can be used in anti-cancer therapeutic compositions useful in the treatment of human cancers.
Claims15
A compound having the structure
- and the derivatives, isomers, enantiomers, tautomers, esters, complexes, and salts thereof, where R1 and R2 are independently selected from the group consisting of H, C1-C4 alkyl groups, and C1-C4 alkoxy groups, R3 and R4 are independently selected from the group consisting of nothing, H, and C1-C2 alkyl groups, and X is selected from the group consisting of (CH2)3 and C3-C8 geminal alkyl groups having a carbon atom therein with two functional groups bound to said carbon atom, said functional groups independently selected from the group consisting of C1-C3 alkyl groups, C1-C3 alcohols, and metal atoms.
A compound having the structure
- and the derivatives, isomers, enantiomers, tautomers, esters, complexes, and salts thereof, where R5 and R6 are independently selected from the group consisting of H, C1-C4 alkyl groups, and C1-C4 alkoxy groups, R7, R8, and R9 are independently selected from the group consisting of H, OH, C1-C4 alkoxy groups, C1-C4 alkyl groups, —N2, and CH2N2, and n2 and n3 are independently 1-4, and R10 and R11 are independently selected from the group consisting of nothing, H, and C1-C2 alkyl groups, and wherein at least one of said R7, R8, or R9 substituents is selected from the group consisting of N2 and CH2N2.
A compound of the structure
Dependencies are inferred from the claim text.