Therapeutic compounds and methods of use thereof

A compound of formula (I)

• or a pharmaceutically acceptable salt thereof, wherein:
• A is a 6-12 membered aryl ring that is optionally substituted with one or more groups RA independently selected from the group consisting of F, Cl, Br, I, —CN, —C(═O)ORA1, —SO2RA1, —ORA1, —(XRA)—(3-15 membered carbocyclyl), —(XRA)-(6 membered aryl), —(XRA)—(5-12 membered heteroaryl), and —RA2, wherein said 3-15 membered carbocyclyl, 6-12 membered aryl, and 5-12 membered heteroaryl of RA is optionally substituted with from 1 to 5 substituents Ra independently selected from the group consisting of F, Cl, Br, I, C1-4alkyl, halo(C1-4alkyl), amino, (C1-4alkyl)amino, di(C1-4alkyl)amino, halo(C1-4alkoxy), and —C(O)N(Rc)2;
• RA1 is selected from the group consisting of hydrogen, C1-8alkyl, C2-8alkenyl, halo(C1-8alkyl), C3-8cycloalkyl, phenyl and benzyl;
• RA2 is selected from the group consisting of C1-8alkyl that is optionally substituted with one or more substituents independently selected from oxo (=O), fluoro, hydroxy, amino, (C1-4alkyl)amino and di(C1-4alkyl)amino;
• XRA is selected from the group consisting of absent, —C(═O)—, and C1-4alkylene;
• wherein any C1-4alkylene, of XRA is optionally substituted with 1 to 3 substituents independently selected from the group consisting of C1-4alkyl, halo(C1-4alkyl), and phenyl that is optionally substituted with 1 to 5 substituents independently selected from, F, Cl, Br, I, —NH2, —OH, —CN, —NO2, C1-4alkyl, halo(C1-4alkyl), C1-4alkoxy, halo(C1-4alkoxy), (C1-4alkyl)amino and di(C1-4alkyl)amino;
• B is a 5-12 membered heteroaryl or a 6-12 membered aryl ring, wherein ring B is optionally substituted with one or more groups RB independently selected from the group consisting of F, Cl, Br, I, —CN, —C(═O)ORB1, —SO2RB1, —ORB1, —(XRB)-(3-15 membered carbocyclyl), —(XRB)-(6-12 membered aryl), —(XRB)-(5-12 membered heteroaryl), and —RB2, wherein said 3-15 membered carbocyclyl, 6-12 membered aryl, and 5-12 membered heteroaryl of RB is optionally substituted with from 1 to 5 substituents Rb independently selected from the group consisting of F, Cl, Br, I, C1-4alkyl, halo(C1-4alkyl), amino, (C1-4alkyl)amino, di(C1-4alkyl)amino, halo(C1-4alkoxy), and —C(O)N(RC)2;
• RB1 is selected from the group consisting of hydrogen, C1-8alkyl, C2-8alkenyl, halo(C1-8alkyl), C3-8cycloalkyl, phenyl and benzyl;
• RB2 is selected from the group consisting of C1-8alkyl that is optionally substituted with one or more substituents independently selected from oxo (=O), fluoro, hydroxy, amino, (C1-4alkyl)amino and di(C1-4alkyl)amino;
• XRB is selected from the group consisting of absent, —C(═O)—, and C1-4alkylene;
• wherein any C1-4alkylene, of XRB is optionally substituted with 1 to 3 substituents independently selected from the group consisting of C1-4alkyl, halo(C1-4alkyl), and phenyl that is optionally substituted with 1 to 5 substituents independently selected from, F, Cl, Br, I, —NH2, —OH, —CN, —NO2, C1-4alkyl, halo(C1-4alkyl), C1-4alkoxy, halo(C1-4alkoxy), (C1-4alkyl)amino and di(C1-4alkyl)amino;
• ring C is a 5-, 6-, or 7-membered heterocyclyl, which 5-, 6-, or 7-membered heterocyclyl is optionally substituted with one or more groups Rc independently selected from the group consisting of C1-4alkyl, halo, oxo (=O), thioxo (=S), and halo(C1-4alkyl);
• R3, R4, and R5 are each independently selected from the group consisting of H, F, Cl, Br, I, —CN, C1-8alkyl, C3-8cycloalkyl, halo(C1-4alkyl) and C1-8alkoxy;
• and
• R6 is selected from the group consisting of H, C1-8alkyl, C3-8 cycloalkyl, aryl, and aryl(C1-4 alkyl);
• and R7 is selected from the group consisting of C1-8alkyl, 3-15 membered heterocyclyl, 5-12 membered heteroaryl, —C(O)N(Rd)2 and —C(═NCN)N(Rd)2;
• or R6 and R7, together with the nitrogen to which they are attached, form a 3-15 membered heterocyclyl or 5-12 membered heteroaryl;
• wherein any C1-8 alkyl, C3-8 cycloalkyl, aryl, aralkyl, 3-15 membered heterocyclyl, and 5-12 membered heteroaryl is optionally substituted with one or more groups Re that are independently selected from the group consisting of F, Cl, Br, I, —NH2, —OH, —CN, —NO2, C1-4 alkyl, halo(C1-4alkyl), C1-4alkoxy, halo(C1-4alkoxy), (C1-4alkyl)amino and di(C1-4alkyl)amino;
• each Rd is independently selected from the group consisting of hydrogen, C1-8 alkyl, C3-8 cycloalkyl, phenyl and benzyl.