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US 10,947,248 B2Granted
4β-amidotriazole linked podophyllotoxin derivatives as potential anticancer agents
AssigneeCouncil of Scientific and Industrial Research
InventorsAhmed Kamal, Velma Ganga Reddy, Ayinampudi Venkata Subbarao, Syed Riyaz, Vadithe Lakshma Nayak, Shaik Taj
Life of this patent
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Abstract
The present invention relates to a compound of general formula (A). The invention provides asynthesis of new 4β-amidotriazole linked podophyllotoxin derivatives of general formulae 8a-z to 9a-z useful as potential anticancer agents against human cancer cell lines and process for the preparation thereof. Wherein n=0, 1 and R1-R5═[H, CI, F, CH3, OCH3, 3,4(-OCH2O—), CF3, OCF3, m-OC6H5, OH]
Claims5
A compound of 4β-Amidotriazole linked podophyllotoxin congeners of general formula A:
- wherein n=0,1 and
- R1-R5═[H, Cl, F, CH3, OCH3, 3,4(-OCH2O—), CF3, OCF3, m-OC6H5, OH].
Dependencies are inferred from the claim text.