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US 10,947,241 B2Granted
Phenyl phthalazine derivative, method for the preparation thereof, and pharmaceutical composition comprising the same
AssigneeSeoul National University Hospital
InventorsJa Kyung Yoo, Nora Lee, Chun Ho Lee, Myunggi Jung, Hyo-Soo Kim
Life of this patent
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Abstract
The present invention relates to a compound represented by Chemical Formula 1, or a pharmaceutically acceptable salt thereof. The compound according to the present invention can be usefully used for the prevention or treatment of cardiovascular diseases.
Claims6
A compound represented by the following Chemical Formula 1, or a pharmaceutically acceptable salt thereof:
- in Chemical Formula 1,
- X is N,
- L1 is a single bond, C1-4 alkylene, C2-4 alkenylene, NH, O, or SO2,
- L3 is a single bond,
- R1 is hydrogen, C1-4 alkyl, C1-4 alkyl substituted with carboxy group, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, halogen, cyano, nitro, 4-methylpiperazin-1-carbonyl, carboxy, morpholino, (C1-4 alkyl)sulfonyl, (piperidinyl)sulfonyl, or (piperazinyl)sulfonyl,
- R3 is hydrogen, or C1-4 alkyl,
- R4 is hydrogen, or halogen,
- n is 1 or 2, and
- A-L2-R2 is represented by the following formula 1′:
- in Chemical Formula 1′,
- Y is N, is a single bond,
- Z is CH, or N,
- n1 is 1,
- n2 is 1 or 2,
- L2 is NH, and
- R2 is C1-4 alkyl unsubstituted or substituted with amino;
- C3-6 cycloalkyl;
- amino;
- N(C1-4 alkyl)2;
- hydroxy;
- morpholino;
- or pyrrolidinyl.
19 more elements
Dependencies are inferred from the claim text.