Anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases

A compound of the formula:

• including pharmaceutically acceptable salts and stereoisomers of said compound, wherein:
• Xa and Xb are independently selected from the group consisting of H and CH3;
• Ya, Yb and Yc may be the same or different and are selected from the group consisting of H, halogen and (C1-C3)-alkoxy;
• Za, Zb and Zc are the same or different and are selected from the group of H, (C1-C3)-alkoxy, (C1-C4)-alkyl, COOH, CONR10R11, 2-oxazole, 2-oxazoline and 2-benzoxazole;
• wherein R10 and R11 are independently selected from the group of H, optionally substituted (C1-C3)-alkyl and optionally substituted aryl;
• and
• n=2;
• wherein either:
• (i) Xa is methyl;
• one of Ya, Yb and Yc is substituted at the 5-position or the 7-position of the benzofuran ring and is methoxy and the others are H;
• one of Za, Zb and Zc is substituted at the 4-position of the benzene ring and is selected from the group of CONR10R11, methylaminocarbonyl, branched (C3-C4)-alkyl, methoxy, 2-oxazolyl, 4,5-dihydro-oxazol-2-yl, and 2-benzoxazole substituents, and the others are H, wherein R10 and R11 are independently selected from the group of H, optionally substituted (C1-C3)-alkyl and optionally substituted aryl;
• or
• (ii) Xa is methyl;
• one of Ya, Yb and Yc is substituted at the 5-position or the 7-position of the benzofuran ring and is methoxy and the others are H;
• one of Za, Zb and Zc is substituted at the 3-position of the benzene ring and is selected from the group of CONR10R11, methylaminocarbonyl, branched (C3-C4)-alkyl, methoxy, 2-oxazolyl, 4,5-dihydro-oxazol-2-yl, and 2-benzoxazole substituents, and the others are H, wherein R10 and R11 are independently selected from the group of H, optionally substituted (C1-C3)-alkyl and optionally substituted aryl.