Oxazolidinone compounds and methods of use thereof as antibacterial agents

A compound of formula I

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is —CH2N(R2)2, or —CH2NR2COOR3;
• each occurrence of R2 is independently H, or C1-C6 alkyl;
• R3 is H or C1-C6 alkyl;
• E is a 6-membered aryl or a 6-membered heteroaryl containing N, wherein the aryl is substituted with two substituents, which are independently selected from halogen, —CN, —CF3, —CHF2, —CH2NH2, —CH2NHCOCH3, —OCF3, —OCHF2, —OH, —O—(C1-C6)alkyl, C1-C6 alkyl, and C3-C6 cycloalkyl and said heteroaryl is optionally substituted with up to four substituents, which are independently selected from halogen, —CN, —CF3, —CHF2, —CH2NH2, —CH2NHCOCH3, —OCF3, —OCHF2, —OH, —O—(C1-C6)alkyl, C1-C6 alkyl, and C3-C6 cycloalkyl and wherein when E is aryl R1 is not —CH2N(R2)2;
• A is
• and optionally substituted with up to four R8, wherein each occurrence of R8 is independently selected from halogen, C1-C6 alkyl, C3-C6 cycloalkyl, C3-C6 heterocycloalkyl, benzyl, —OCF3, —OCHF2, —OR3, ═O, —CN, —NO2, —SR3, —SF5, —SCF3, —SOR3, —SO2R3, —S(═O)(═NH)R2, —N(R2)2, —NR2COR3, —SO2N(R2)2, —NR2SO2R3, —COOH, —COR9, —COOR3, —CON(R2)2, and —C(R9)2N(R2)2, wherein said C1-C6 alkyl, C3-C6 cycloalkyl, C3-C6 heterocycloalkyl, and benzyl are optionally substituted with up to four F, —OCH3, —OH, ═O, NH2, NHCH3, and N(CH3)2;
• each occurrence of R9 is independently selected from H, C1-C6 alkyl, and C3-C6 cycloalkyl;
• and
• W is SO2.