Certain chemical entities, compositions, and methods

A compound having the following formula:

• or a pharmaceutically acceptable salt thereof, wherein:
• X10 is C—R35;
• is aryl or heteroaryl;
• each of R3, R4, R5 and R6 is independently hydrogen, cyano, fluoro, or chloro;
• R34, R35, R36, R37, and R38 are independently hydrogen, cyano, halo, optionally substituted alkoxy, optionally substituted heterocycloalkyloxy, optionally substituted heterocycloalkyl, optionally substituted amino, or E;
• each Q is independently hydrogen, cyano, or halo;
• wherein E is
• and
• m is 0, 1, or 2;
• wherein at least one of R34, R35, R36, R37, and R38 is E;
• wherein:
• each substituted alkoxy is —O-(substituted alkyl);
• each substituted amino is —NHRd or —NRdRe;
• wherein each Rd is independently unsubstituted or substituted alkyl, or unsubstituted or substituted heterocycloalkyl;
• and each Re is independently unsubstituted or substituted alkyl, or unsubstituted or substituted heterocycloalkyl;
• and
• each substituted alkyl and substituted heterocycloalkyl is substituted with one or more groups independently selected from —Ra, —ORb, —NH2—NHRd, —NRdRe, and halo;
• each Ra is independently unsubstituted or substituted C1-C6 alkyl;
• each Rb is independently hydrogen or unsubstituted or substituted C1-C6 alkyl;
• each Rd is independently unsubstituted or substituted alkyl;
• and each Re is independently unsubstituted or substituted alkyl;
• wherein when any Ra, Rb, Rd, or Re group is substituted, the Ra, Rb, Rd, or Re group is substituted with one or more substituents independently selected from a group D consisting of C1-C4 alkyl, C1-C4 haloalkyl, —OC1-C4 alkyl, halo, —OH, —NH2, —N(C1-C4 alkyl)(C1-C4 alkyl), and —NH(C1-C4 alkyl).