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US 10,947,180 B2Granted
Phenoxy acetic acids and phenyl propionic acids as PPAR delta agonists
AssigneevTv Therapeutics LLC
InventorsPer Sauerberg, Pavel Pihera, Zdenek Polivka, Miroslav Havranek, Ingrid Petterson, John Patrick Mogensen
Life of this patent
Estimating the term…
Abstract
Phenoxy acetic acids and phenyl propionic acids and their use in improving mitochondrial energy output in a subject are provided herein. The present compounds are activators of PPARδ and may be useful for treating conditions mediated by the same.
Claims11
A compound of formula (I) or a pharmaceutically acceptable salt thereof:
- wherein is a double bond, with either E or Z substitution;
- X1 is C1-6 alkyl substituted with morpholino;
- X2 is phenylene;
- X3 is phenyl substituted with one or more halogens;
- Ar is phenylene optionally substituted with methyl;
- Y1 is O;
- Y2 is O;
- Z is CH2;
- R1 is hydrogen;
- and
- R2 is C1-6-alkyl.
8 more elements
A pharmaceutically acceptable salt of a compound of formula (I):
- wherein is a double bond, with either E or Z substitution;
- X1 is C1-6 alkyl substituted with morpholino;
- X2 is phenylene;
- X3 is phenyl substituted with one or more halogens;
- Ar is phenylene optionally substituted with methyl;
- Y1 is O;
- Y2 is O;
- Z is CH2;
- R1 is hydrogen;
- and
- R2 is C1-6-alkyl.
8 more elements
A compound that is:
- methyl (E)-[4-[3-(4-fluorophenyl)-3-[4-[3-(morpholin-4-yl)propynyl]phenyl]allyloxy]-2-methyl-phenoxy]acetate;
- or
- methyl (Z)-[4-[3-(4-fluorophenyl)-3-[4-[3-(morpholin-4-yl)propynyl]phenyl]allyloxy]-2-methylphenoxy]acetate;
- or a pharmaceutically acceptable salt thereof.
1 more element
Dependencies are inferred from the claim text.