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US 10,947,177 B2Granted
Compounds and methods for delivery of prostacyclin analogs
AssigneeUnited Therapeutics Corporation
InventorKen Phares
Life of this patent
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Abstract
This invention pertains generally to prostacyclin formulations and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis.
Claims48
An ester compound of formula:
- wherein R1 and R2 are H and R3 is selected from the group consisting of phosphate and groups in which OR3 forms an ester of an amino acid or a protein;
- an enantiomer of the compound;
- or a pharmaceutically acceptable salt of the compound.
Dependencies are inferred from the claim text.