Ergonomic pipette tips

A pipette tip comprising an exterior surface, an interior surface, a proximal region, a distal region and a junction between the proximal region and the distal region, the proximal region comprising:

• a proximal terminus,
• a distal terminal shoulder at the junction,
• longitudinally-oriented grooves on the exterior surface of the pipette tip circumferentially distributed around the proximal region, and
• longitudinally-oriented panels on the exterior surface of the pipette tip circumferentially distributed around the proximal region, wherein:
• each panel is adjacent to a groove;
• each panel or a portion thereof extends over a sealing zone;
• each panel comprises a panel sidewall, a panel face and a panel width;
• each groove comprises a groove width and a groove floor;
• each groove or a portion thereof extends over the sealing zone;
• each panel width is at least five times greater than each groove width;
• and
• the interior surface of the pipette tip defines a frustum-shaped void and is smooth and uniform.