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US 10,946,343 B2Granted
Acrylonitrile-based membrane with improved performance
AssigneeGambro Lundia AB
InventorBenjamin Malard
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Abstract
The present disclosure relates to improved semipermeable membranes based on acrylonitrile copolymers for use in dialyzers for the extracorporeal treatment of blood in conjunction with hemodialysis, hemofiltration or hemodiafiltration. The present disclosure further relates to methods of producing such membranes.
Claims26
A membrane comprising i) a copolymer of acrylonitrile and sodium methallylsulfonate and ii) water, characterized in that the water content of the membrane under ATPS conditions is in the range of from about 70 wt.-% to about 75 wt.-%, relative to the total weight of the membrane, and
- wherein the membrane is prepared according to steps comprising:
- (a) forming a polymer composition comprising i) acrylonitrile and sodium methallylsulfonate in a molar ratio of between 90:10 and 99:1, ii) a solvent selected from the group consisting of DMF, DMSO and NMP;
- and iii) glycerol;
- (b) heating the composition formed in step (a);
- (c) passing the composition of step (b) through a spinning nozzle comprising i) two concentric rings which enclose the polymer composition and ii) a center opening which is perfused with an inert gas to make a preformed hollow fiber;
- (d) passing the preformed hollow fiber of step (c) into a spinning bath, wherein the spinning bath has a temperature in the range of from about 25° C. to about 50° C.;
- and
- (e) thereafter subjecting the hollow fiber of step (d) to an operation of stretching at a stretching ratio in a range from about 3.6 to about 4.5.
5 more elements
Dependencies are inferred from the claim text.