Method for producing cocrystals by means of flash evaporation
AssigneesCentre National de la Recherche Scientifique (CNRS), Universite De Strasbourg, I.S.L. Institut Franco-Allemand de Recherches de Saint-Louis
InventorsBenedikt Risse, Denis Spitzer, Florent Pessina
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Abstract
The invention relates to a method for producing a cocrystal of at least two compounds by means of instantaneous evaporation or flash evaporation, for example for the production of cocrystals in the fields of energetic materials, pharmaceutical compounds, phytopharmaceutical compounds, ferroelectric materials, non-linear response materials or bioelectronic materials.
Claims27
A method for preparing a co-crystal of at least two compounds, comprising:
- providing at least two organic, mineral, or organometal compounds which may be bound each other by hydrogen bonds, ionic bonds, bonds of the stacking type (π-π stacking) or Van der Waals bonds;
- preparing a solution comprising at least one solvent and said at least two compounds to be co-crystalsized, wherein said preparation comprises dissolving said at least two compounds in said at least one solvent;
- heating the solution, under a pressure ranging from 3 to 300 bars, at a temperature above the boiling point of the solvent or at a temperature above the boiling point of the mixture of solvents;
- atomizing the solution in an atomization chamber with at least one dispersion device and under an angle ranging from 30 to 150° at a pressure ranging from 0.0001 to 2 bars;
- separating the solvent or solvents in gaseous form;
- and
- obtaining at least a co-crystal of said at least two compounds assembled on a molecular scale.
A method for preparing a co-crystal of at least two compounds comprising successively:
- providing at least two organic, mineral, or organometal compounds which may be bound each other by hydrogen bonds, ionic bonds, bonds of the stacking type (π-π stacking) or Van der Waals bonds;
- preparing at least two solutions each comprising at least one solvent and said at least one compound, wherein each preparation comprises dissolving said compound in said solvent;
- heating the solutions, under a pressure ranging from 3 to 300 bars, at a temperature above the boiling point of the solvent or at a temperature above the boiling point of the mixture of solvents;
- atomizing the solutions in a same atomization chamber with at least one dispersion device and under an angle ranging from 30 to 150° at a pressure ranging from 0.0001 to 2 bars;
- separating the solvents in a gaseous form;
- and
- obtaining at least a co-crystal of said at least two compounds assembled on a molecular scale.
Dependencies are inferred from the claim text.