# US 10,946,197 B2 · Treatment of conditions through modulation of the autonomic nervous system

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- Number: US 10,946,197 B2
- Document ID: US10946197B2
- Status: Granted
- Kind: B2
- Application number: 12/774,616
- Filed: 2010-05-05
- Published: 2010-11-11
- Granted: 2021-03-16
- Earliest claimed: 2003-06-09
- Assignees: Palo Alto Investors
- Applicants: Anthony Joonkyoo Yun; Patrick Yuarn-Bor Lee
- Inventors: Anthony Joonkyoo Yun; Patrick Yuarn-Bor Lee
- Web page: https://patentgrep.com/patent/US10946197B2

## CPC

- A61N 1/36053: {adapted for vagal stimulation (A61N1/36114 takes precedence)}
- A61N 1/0551: {Spinal or peripheral nerve electrodes}
- A61N 1/326: {for promoting growth of cells, e.g. bone cells}
- A61N 1/36017: {with leads or electrodes penetrating the skin}
- A61N 1/3605: {Implantable neurostimulators for stimulating central or peripheral nerve system}
- A61N 1/36071: {Pain}
- A61N 1/36117: {for treating hypertension}
- A61N 1/37235: {Aspects of the external programmer}
- A61N 1/36021: {for treatment of pain}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

Methods are provided for treating a subject for a condition by modulating at least a portion of the subject's autonomic nervous system. In accordance with certain embodiments of the subject methods, at least a portion of a subject's autonomic nervous system is electrically or pharmacologically modulated in a manner that is effective to treat the subject for the condition. The subject methods find use in the treatment of a variety of different conditions, where such conditions include various disease conditions. Also provided are systems and kits for use in practicing the subject methods.

## Claims

### Claim 1

A method of treating a subject for a condition associated with a systemic loss of parasympathetic function, the method comprising:
measuring the subject's parasympathetic/sympathetic activity ratio to detect that the subject has the systemic loss of parasympathetic function; and
electrically modulating at least a portion of the parasympathetic nervous system of the subject, based on the subject's detected systemic loss of parasympathetic function, with an electrical energy application device to modulate the parasympathetic activity/sympathetic activity ratio in a manner effective to treat said subject for the condition, wherein the condition is multi-system atrophy.

### Claim 2

A method of treating a subject for a condition associated with a systemic loss of parasympathetic function, the method comprising:
measuring the subject's parasympathetic/sympathetic activity ratio to detect that the subject has the systemic loss of parasympathetic function; and
administering a pharmacological agent to the subject, based on the subject's detected systemic loss of parasympathetic function, sufficient to provide systemic pharmacological modulation of said subject's autonomic nervous system to modulate the parasympathetic activity/sympathetic activity ratio in a manner effective to treat said subject for the condition, wherein the condition is multi-system atrophy.