# US 10,946,164 B2 · Valve controlled high frequency oscillatory ventilation > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,946,164 B2 - Document ID: US10946164B2 - Status: Granted - Kind: B2 - Application number: 14/429,922 - Filed: 2012-09-21 - Published: 2015-08-27 - Granted: 2021-03-16 - Earliest claimed: 2012-09-21 - Assignees: Maquet Critical Care AB - Applicants: Maquet Critical Care AB - Inventors: Stefan Lindström; Carl Erik Troili; Magnus Hallbäck - Web page: https://patentgrep.com/patent/US10946164B2 ## CPC - A61M 16/204: {used for inhalation control} - A61M 16/0003: {Accessories therefor, e.g. sensors, vibrators, negative pressure} - A61M 16/0009: {with sub-atmospheric pressure, e.g. during expiration} - A61M 16/0057: {Pumps therefor} - A61M 16/0096: {High frequency jet ventilation} - A61M 16/205: {used for exhalation control} - A61M 16/12: by mixing different gases - A61M 16/206: {Capsule valves, e.g. mushroom, membrane valves} - A61M 2016/0021: {with a proportional output signal, e.g. from a thermistor} - A61M 2016/0027: {pressure meter} - A61M 2016/0036: {in the breathing tube and used in both inspiratory and expiratory phase} - A61M 2016/0039: {in the inspiratory circuit} - A61M 2016/0042: {in the expiratory circuit} - A61M 2205/3334: Measuring or controlling the flow rate - A61M 2205/52: with memories providing a history of measured variating parameters of apparatus or patient - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A breathing apparatus provides high frequency oscillatory ventilation [HFO] to a patient by supplying breathing gas to the patient according to an oscillating pressure profile oscillating between a positive pressure and a negative pressure. The breathing apparatus has a patient circuit including an inspiratory line for conveying breathing gas to the patient, and an expiratory line for conveying gas away from the patient, and an inspiration valve for regulating a flow of pressurised breathing gas into the inspiration line, and a control computer that controls the inspiration valve. The control computer operates to cause the oscillating pressure profile by controlling the inspiration valve to oscillate between a top flow position in which the flow of breathing gas through the inspiration valve assumes a top flow value, and a minimum flow position in which the flow through the inspiration valve assumes a minimum flow value. ## Claims ### Claim 1 A breathing apparatus for providing high frequency oscillatory ventilation [HFO] to a patient by supplying breathing gas to the patient according to an oscillating pressure profile oscillating between a positive pressure and a negative pressure, comprising: a patient circuit including an inspiratory line for conveying breathing gas to the patient, and an expiratory line for conveying gas away from the patient; a controllable inspiration valve for regulating a flow of pressurised breathing gas into the inspiration line; a control computer configured to control the inspiration valve and to generate positive and negative pressure components of the oscillating pressure profile by controlling the inspiration valve to oscillate between a top flow position in which the flow of breathing gas through the inspiration valve assumes a top flow value, and a minimum flow position in which the flow through the inspiration valve assumes a minimum flow value, wherein the positive pressure components are generated by an opening of the inspiration valve to the top flow position, allowing breathing gas to flow through the inspiration valve at the top flow value, and the negative pressure components are generated by a closing of the inspiration valve to the minimum flow position causing a deceleration of the breathing gas flow from the top flow value to the minimum flow value; and an electronically controlled expiration valve regulating the flow of gas through the expiratory line, wherein the control computer is configured to cause the expiration valve to oscillate with an oscillation pattern that is out of phase with the oscillation pattern of the inspiration valve, wherein the control computer is configured to, in each period of the HFO ventilation, close the expiration valve while the pressure in the patient circuit is negative, and open the inspiration valve with a time delay after closing the expiration valve that produces an increase in the duration of active expiration. ### Claim 2 (depends on 1) The breathing apparatus according to claim 1, wherein the control computer is configured to cause the inspiration valve to go from the top flow position to the minimum flow position with a speed causing a mean rate of change in flow from the top flow value to the minimum flow value of at least 7200 lpm/s. ### Claim 3 (depends on 1) The breathing apparatus according to claim 1, wherein the top flow value is at least 30 lpm. ### Claim 4 (depends on 1) The breathing apparatus according to claim 1, wherein the minimum flow value is at most 4 lpm. ### Claim 5 (depends on 1) The breathing apparatus according to claim 1, wherein the minimum flow value is at most 1 lpm. ### Claim 6 (depends on 1) The breathing apparatus according to claim 1, further comprising a mechanism preventing a reverse flow of gas in the expiratory line. ### Claim 7 (depends on 6) The breathing apparatus according to claim 6, wherein the mechanism for preventing a reverse flow of gas in the expiratory line comprises one of an expiration valve, a mechanical one-way valve, and a length of tubing extending the length of the expiratory line. ### Claim 8 (depends on 6) The breathing apparatus according to claim 6, wherein the mechanism preventing a reverse flow of gas in the expiratory line includes an expiration valve. ### Claim 9 (depends on 1) The breathing apparatus according to claim 1, wherein both the positive and negative pressure components of the oscillating pressure profile are exclusively generated by the oscillating inspiration valve. ### Claim 10 (depends on 1) The breathing apparatus according to claim 1, wherein the minimum flow position is a closed or nearly closed position at which the flow through the inspiration valve is zero or nearly zero. ### Claim 11 (depends on 1) The breathing apparatus according to claim 1, wherein the negative pressure components are generated only by use of kinetic energy of breathing gas pulses injected through the inspiration valve. ### Claim 12 A method for providing FIFO ventilation to a patient by supplying breathing gas to the patient according to an oscillating pressure profile oscillating between a positive pressure and a negative pressure, comprising the steps of: supplying pressurised breathing gas to the patient via a controllable inspiration valve in an inspiratory line of a patient circuit; conveying gas away from the patient via an expiratory line of the patient circuit; generating positive and negative pressure components of the oscillating pressure profile by operating the inspiration valve to oscillate between a top flow position in which the flow of breathing gas through the inspiration valve assumes a top flow value, and a minimum flow position in which the flow through the inspiration valve assumes a minimum flow value, wherein the positive pressure components are generated by an opening of the inspiration valve to the top flow position, allowing breathing gas to flow through the inspiration valve at the top flow value, and the negative pressure components are generated by a closing of the inspiration valve to the minimum flow position causing a deceleration of the breathing gas flow from the top flow value to the minimum flow value; operating an expiration valve in the expiratory line to oscillate with an oscillation pattern that is out of phase with the oscillation pattern of the inspiration valve; and in each period of the HFO ventilation, closing the expiration valve while the pressure in the patient circuit is negative, and opening the inspiration valve with a time delay after closing the expiration valve that produces an increase in the duration of active expiration during expiration phases. ### Claim 13 (depends on 12) The method according to claim 12, further comprising operating the inspiration valve to go from the top flow position to the minimum flow position with a speed causing a mean rate of change in flow from the top flow value to the minimum flow value of at least 7200 lpm/s. ### Claim 14 (depends on 12) The method according to claim 12, wherein the top flow value is at least 30 lpm. ### Claim 15 (depends on 12) The method according to claim 12, wherein the minimum flow value is at most 4 lpm. ### Claim 16 (depends on 12) The method according to claim 12, wherein the minimum flow value is at most 1 lpm. ### Claim 17 (depends on 12) The method according to claim 12, further comprising preventing a reverse flow of gas in the expiratory line. ### Claim 18 (depends on 12) The method according to claim 12, further comprising generating both the positive and negative pressure components of the oscillating pressure profile exclusively by operating the oscillating inspiration valve. ### Claim 19 (depends on 12) The method according to claim 12, wherein the minimum flow position is a closed or nearly closed position at which the flow through the inspiration valve is zero or nearly zero. ### Claim 20 (depends on 12) The method according to claim 12, wherein the negative pressure components are generated only by use of kinetic energy of breathing gas pulses injected through the inspiration valve. ### Claim 21 A non-transitory, computer-readable data storage medium encoded with programming instructions, the storage medium being loaded into a control computer of a breathing apparatus, the breathing apparatus comprising a patient circuit that includes an inspiratory line for conveying breathing gas to a patient and an expiratory line for conveying gas away from the patient, and an inspiration valve for regulating a flow of pressurized breathing gas into the inspiration line, the breathing apparatus being configured to provide high frequency oscillatory ventilation to the patient by supplying breathing gas to the patient according to an oscillating pressure profile that oscillates between a positive pressure and a negative pressure, and the programming instructions causing the control computer to: operate the inspiration valve to generate positive and negative pressure components of the oscillating pressure profile by causing the inspiration valve to oscillate between a top flow position in which the flow of breathing gas through the inspiration valve assumes a top flow value, and a minimum flow position in which the flow through the inspiration valve assumes a minimum flow value, wherein the positive pressure components are generated by an opening of the inspiration valve to the top flow position, allowing breathing gas to flow through the inspiration valve at the top flow value, and the negative pressure components are generated by a closing of the inspiration valve to the minimum flow position causing a deceleration of the breathing gas flow from the top flow value to the minimum flow value; and operate an expiration valve in the expiratory line to oscillate with an oscillation pattern that is out of phase with the oscillation pattern of the inspiration valve, wherein, in each period of the HFO ventilation, the expiration valve is closed while the pressure in the patient circuit is negative, and the inspiration valve is opened with a time delay after closing the expiration valve that produces an increase in the duration of active expiration during expiration phases. ### Claim 22 A breathing apparatus for providing high frequency oscillatory ventilation [FIFO] to a patient by supplying breathing gas to the patient according to an oscillating pressure profile oscillating between a positive pressure and a negative pressure, comprising: a patient circuit including an inspiratory line for conveying breathing gas to the patient, and an expiratory line for conveying gas away from the patient; a controllable inspiration valve for regulating a flow of pressurised breathing gas into the inspiration line; a control computer configured to control the inspiration valve and to generate positive and negative pressure components of the oscillating pressure profile by controlling the inspiration valve to oscillate between a top flow position in which the flow of breathing gas through the inspiration valve assumes a top flow value, and a minimum flow position in which the flow through the inspiration valve assumes a minimum flow value, wherein the positive pressure components are generated by an opening of the inspiration valve to the top flow position, allowing breathing gas to flow through the inspiration valve at the top flow value, and the negative pressure components are generated by a closing of the inspiration valve to the minimum flow position causing a deceleration of the breathing gas flow from the top flow value to the minimum flow value; and an electronically controlled expiration valve regulating the flow of gas through the expiratory line, wherein the control computer is configured to cause the expiration valve to oscillate with an oscillation pattern that is out of phase with the oscillation pattern of the inspiration valve, wherein the control computer is configured to, in each period of the HFO ventilation, keep the expiration valve closed when the inspiration valve is open, and open the expiration valve with a time delay after closing the inspiration valve that produces an increase in the flow of breathing gas into the airways of the patient during inspiration phases. ### Claim 23 A method for providing HFO ventilation to a patient by supplying breathing gas to the patient according to an oscillating pressure profile oscillating between a positive pressure and a negative pressure, comprising the steps of: supplying pressurised breathing gas to the patient via a controllable inspiration valve in an inspiratory line of a patient circuit; conveying gas away from the patient via an expiratory line of the patient circuit; generating positive and negative pressure components of the oscillating pressure profile by operating the inspiration valve to oscillate between a top flow position in which the flow of breathing gas through the inspiration valve assumes a top flow value, and a minimum flow position in which the flow through the inspiration valve assumes a minimum flow value, wherein the positive pressure components are generated by an opening of the inspiration valve to the top flow position, allowing breathing gas to flow through the inspiration valve at the top flow value, and the negative pressure components are generated by a closing of the inspiration valve to the minimum flow position causing a deceleration of the breathing gas flow from the top flow value to the minimum flow value; operating an expiration valve in the expiratory line to oscillate with an oscillation pattern that is out of phase with the oscillation pattern of the inspiration valve; and in each period of the HFO ventilation, keeping the expiration valve closed when the inspiration valve is open, and opening the expiration valve with a time delay after closing the inspiration valve that produces an increase in the flow of breathing gas into the airways of the patient during inspiration phases. ### Claim 24 A non-transitory, computer-readable data storage medium encoded with programming instructions, the storage medium being loaded into a control computer of a breathing apparatus, the breathing apparatus comprising a patient circuit that includes an inspiratory line for conveying breathing gas to a patient and an expiratory line for conveying gas away from the patient, and an inspiration valve for regulating a flow of pressurized breathing gas into the inspiration line, the breathing apparatus being configured to provide high frequency oscillatory ventilation to the patient by supplying breathing gas to the patient according to an oscillating pressure profile that oscillates between a positive pressure and a negative pressure, and the programming instructions causing the control computer to: operate the inspiration valve to generate positive and negative pressure components of the oscillating pressure profile by causing the inspiration valve to oscillate between a top flow position in which the flow of breathing gas through the inspiration valve assumes a top flow value, and a minimum flow position in which the flow through the inspiration valve assumes a minimum flow value, wherein the positive pressure components are generated by an opening of the inspiration valve to the top flow position, allowing breathing gas to flow through the inspiration valve at the top flow value, and the negative pressure components are generated by a closing of the inspiration valve to the minimum flow position causing a deceleration of the breathing gas flow from the top flow value to the minimum flow value; and operate an expiration valve in the expiratory line to oscillate with an oscillation pattern that is out of phase with the oscillation pattern of the inspiration valve, wherein, in each period of the HFO ventilation, the expiration valve is kept closed when the inspiration valve is open, and the expiration valve is opened with a time delay after closing the inspiration valve that produces an increase in the flow of breathing gas into the airways of the patient during inspiration phases.