# US 10,946,126 B2 · Electrocardiography triggered piston pump

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- Number: US 10,946,126 B2
- Document ID: US10946126B2
- Status: Granted
- Kind: B2
- Application number: 16/151,786
- Filed: 2018-10-04
- Published: 2019-04-25
- Granted: 2021-03-16
- Earliest claimed: 2017-10-04
- Assignees: University of Louisiana at Lafayette
- Applicants: University of Louisiana at Lafayette
- Inventors: Charles Taylor; Jacob King
- Web page: https://patentgrep.com/patent/US10946126B2

## CPC

- A61M 60/424: for positive displacement blood pumps
- A61M 60/258: Piston pumps
- A61M 60/441: generated by an electromotor
- A61M 60/50: Details relating to control
- A61M 60/515: Regulation using real-time patient data
- A61M 60/538: Regulation using real-time blood pump operational parameter data, e.g. motor current
- A61M 60/894: Passive valves, i.e. valves actuated by the blood
- A61M 2205/3606: cooled
- A61M 2205/366: by liquid heat exchangers
- A61M 2230/06: Heartbeat rate only
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

A positive displacement pump that triggers with the beating of a mammalian heart, through the monitoring of an ECG signal is disclosed. A programmable delay from the detection of the forthcoming contraction of the heart enables the pump to syncopate the ejection of the fluid with the events occurring in the cardiovascular system. This delayed ejection could be used to overlay the ejected fluid from the pump with a pressure wave in the artery of systemic circulation through a catheter connection between the pump and a physiological model (e.g., cow, dog, human). The outcome of this use could be to raise the pulse pressure in the system to take advantage of physiological pathways that respond to this transient change in blood pressure. The novelty of this system stems from the adaptable control architecture designed to augment the pulsatile characteristics of the cardiovascular system. This inventive concept could be expanded to encompass the augmentation (dampen or enhance) of pulsatile characteristics in any oscillating flow system.

## Claims

### Claim 1

A biocompatible positive displacement pump that triggers with the beating of a mammalian heart comprising:
(a) a frame system;
(b) a pump unit, comprising:
(i) a pump head system;
(ii) a pump casing component; and
(iii) a drive train system, comprising a motor drive power supply;
(c) an electronics system, comprising:
(i) an electronics power supply;
(ii) a microcontroller, comprising an operating code, which comprises:
(1) an electrocardiogram (ECG) trigger subsystem;
(2) a position encoder processing subsystem;
(3) an operating controls subsystem;
(4) an overwrite and error control subsystem;
(5) a readback processing subsystem; and
(6) programming to operate the pump;
(iii) an interface board;
(iv) a sensor shield;
(v) an ECG signal condition board;
(vi) a motion controller;
(vii) at least one limit switch;
(viii) an actuator;
(ix) a quadrature encoder; and
(x) at least one user control;
wherein the microcontroller is connected to the interface board, the sensor shield, the ECG signal conditioning board, and the motion controller; wherein the interface board provides as least one output signal from the microcontroller to at least one Bayonet Neill-Concelman (BNC) connector;
wherein the sensor shield is connected to the at least one user control, the at least one limit switch, and the quadrature encoder;
wherein the ECG signal conditioning shield connects to an ECG wiring harness; and
wherein the pump is operated using the at least one user control;
wherein the frame system provides a mounting point for the pump head and electronics system; and
wherein the electronics system is operatively connected to the pump unit.

### Claim 2

A biocompatible positive displacement pump that triggers with the beating of a mammalian heart comprising:
(a) a frame system;
(b) a pump unit, comprising:
(i) a pump head system;
(ii) a pump casing component; and
(iii) a drive train system, comprising a motor drive power supply;
(c) an electronics system, comprising:
(i) an electronics power supply;
(ii) a microcontroller, comprising an operating code, which comprises programming to operate the pump and an operating control subsystem, wherein the operating controls subsystem comprises:
(1) an action to motor;
(2) an operating states table; and
(3) a subsystem governs actuation motion;
(iii) an interface board;
(iv) a sensor shield;
(v) an electrocardiogram (ECG) signal condition board;
(vi) a motion controller;
(vii) at least one limit switch;
(viii) an actuator;
(ix) a quadrature encoder; and
(x) at least one user control;
wherein the microcontroller is connected to the interface board, the sensor shield, the ECG signal conditioning board, and the motion controller; wherein the interface board provides as least one output signal from the microcontroller to at least one Bayonet Neill-Concelman (BNC) connector;
wherein the sensor shield is connected to the at least one user control, the at least one limit switch, and the quadrature encoder;
wherein the ECG signal conditioning shield connects to an ECG wiring harness; and
wherein the pump is operated using the at least one user control;
wherein the frame system provides a mounting point for the pump head and electronics system; and
wherein the electronics system is operatively connected to the pump unit.

### Claim 3

A biocompatible positive displacement pump that triggers with the beating of a mammalian heart comprising:
(a) a frame system;
(b) a pump unit, comprising:
(i) a pump head system;
(ii) a pump casing component; and
(iii) a drive train system, comprising a motor drive power supply;
(c) an electronics system, comprising:
(i) an electronics power supply;
(ii) a microcontroller, comprising an operating code comprising programming to operate the pump, and wherein the operating code is configured to match the pump head system's geometry;
(iii) an interface board;
(iv) a sensor shield;
(v) an electrocardiogram (ECG) signal condition board;
(vi) a motion controller;
(vii) at least one limit switch;
(viii) an actuator;
(ix) a quadrature encoder; and
(x) at least one user control;
wherein the microcontroller is connected to the interface board, the sensor shield, the ECG signal conditioning board, and the motion controller; wherein the interface board provides as least one output signal from the microcontroller to at least one Bayonet Neill-Concelman (BNC) connector;
wherein the sensor shield is connected to the at least one user control, the at least one limit switch, and the quadrature encoder;
wherein the ECG signal conditioning shield connects to an ECG wiring harness; and
wherein the pump is operated using the at least one user control;
wherein the frame system provides a mounting point for the pump head and electronics system; and
wherein the electronics system is operatively connected to the pump unit.

### Claim 4

A biocompatible positive displacement pump that triggers with the beating of a mammalian heart comprising:
(a) a frame system;
(b) a pump unit, comprising:
(i) a pump head system;
(ii) a pump casing component; and
(iii) a drive train system, comprising a motor drive power supply;
(c) an electronics system, comprising:
(i) an electronics power supply;
(ii) a microcontroller, comprising an operating code comprising programming to operate the pump, comprising:
(1) an electrocardiogram (ECG) trigger subsystem;
(2) a position encoder processing subsystem;
(3) an operating controls subsystem, comprising:
a. an action to motor;
b. an operating states table, comprising:
1. a prime state;
2. a pause/idle state;
3. a pump on trigger state; and
4. a pump without trigger state;
(iii)c. a subsystem governs actuation motion;
(4) an overwrite and error control subsystem; and
(5) a readback processing subsystem
(iii) an interface board;
(iv) a sensor shield;
(v) an ECG signal condition board;
(vi) a motion controller;
(vii) at least one limit switch;
(viii) an actuator;
(ix) a quadrature encoder; and
(x) at least one user control;
wherein the microcontroller is connected to the interface board, the sensor shield, the ECG signal conditioning board, and the motion controller; wherein the interface board provides as least one output signal from the microcontroller to at least one Bayonet Neill-Concelman (BNC) connector;
wherein the sensor shield is connected to the at least one user control, the at least one limit switch, and the quadrature encoder;
wherein the ECG signal conditioning shield connects to an ECG wiring harness; and
wherein the pump is operated using the at least one user control;
wherein the frame system provides a mounting point for the pump head and electronics system; and
wherein the electronics system is operatively connected to the pump unit.